Structural change in the cellular prion protein, PrPC to a ProteinaseK‐resistant β‐sheet‐rich insoluble form PrPSC and its accumulation have been considered to be central to the pathogenesis of the prion diseases (TSE). In a recent paper, Deleault et al have shown that specific endogenous RNA molecules can induce in vitro structural conversion of endogenous PrPC to PrPSC.1 Small highly structured synthetic RNAs can also induce this conversion process.2 However, recent in vivo results show that PrPSC is not directly involved in (...) the prion pathogenesis.3 It is possible, however, that nucleic‐acid‐induced PrPSC associated with the inducer nucleic acid could be the components of the infectious agent. BioEssays 26:469–473, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

This paper describes a traditional SIR type epidemic model with saturated infection rate and treatment function. The dynamics of the model is studied from the point of view of stability and bifurcation. Basic reproduction number is obtained and it is shown that the model system may possess a backward bifurcation. The global asymptotic stability of the endemic equilibrium is studied with the help of a geometric approach. Optimal control problem is formulated and solved. Some numerical simulation works are carried out (...) to validate our analytical results. (shrink)

Purpose: The purpose of the study was to assess the role of the Faith Based Organizations in alleviating poverty in Western Kenya.Methodology: This study is a cross-sectional research that sought to give an examining and descriptive scrutiny of the death beliefs surrounding FBO’s activities in Emuhaya District. This study targeted Emuhaya District which has a population of 180,000 people who are members of the FBO’s. To obtain data for analysis, qualitative methods of data collection, which include in-depth oral interviews, focus (...) group discussion, observation and documentary analysis, were employed. Questionnaires were prepared and administered according to the information required from the specific groups of respondents. This study utilized secondary sources, which were derived from published books, minutes of developmental meetings in the FBO, reports of the development projects of the church, articles and records from Kenya National Archives. Data collected through the questionnaires and personal interviews, was synthesized systematically and logically compiled to determine the role of FBO in alleviating poverty in Emuhaya District. Data was coded manually and organized under different themes. The researcher then investigated the concepts of liberation and reconstruction in improving the well-being of the poor through an analysis and interpretation of the theological methods of induction (TMI).Results: Based on the findings the study concluded that the CoG-K’s teachings are largely pertinent in the development of FBO members and their participation in activities that are designed along people’s development needs. Also, the CoG-K has a role to play through her programs like Sisi kwa Sisi and Child Development Centres.Unique contribution to theory, practice and policy: This research recommends that if Emuhaya District is to develop, it has to place the FBO teachings and theology of option for the poor at the top of the agenda and to consider it as is so often the case, as adjunct to the real core of the work that is, development. The study proposes that for the FBO to improve her input in social concerns of the people, it should reshape its theology of development so that it can fully address the plight of the poor. (shrink)

These six essays present an outsider's view of Western norms of progress, rationality, and maturity, and offer an alternate perspective on oppression in modern times. Well-known psychologist and social theorist Ashis Nandy stresses the importance of considering world views held by the "non-modern" cultures of the Third World in formulating a more humane and less technologically preoccupied vision of progress. Institutionalized oppression is seen as a process which co-opts the physical and psychological worlds of its victims and destroys the basis (...) of all dissenting visions of a just world. Concluding with an essay on Gandhi and his critical reaction to Western civilization, this book is an important contribution to political science, sociology, psychology, and South Asian studies. (shrink)

Business and Society Review, Volume 126, Issue 1, Page 69-99, Spring 2021.

Commentary on Tattvārthādhigamasūtra of Umāsvāti, ca. 135-ca. 219, on Jaina philosophy.

This paper contributes to biodiversity and species extinction literature by examining the relationship between corporate accountability in terms of species protection and factors affecting such accountability from forward-thinking companies. We use triangulation of theories, namely deep ecology, legitimacy, and we introduce a new perspective to the stakeholder theory that considers species as a ‘stakeholder’. Using Poisson pseudo-maximum likelihood regression, we examine a sample of 200 Fortune Global companies over 3 years. Our results indicate significant positive relations between ecologically conscious companies (...) that are accountable for the protection of biodiversity and species extinction and external assurance, environmental performance, partnerships with socially responsible organizations and awards for sustainable activities. Our empirical results appear to be robust in controlling for possible endogeneities. Our findings contribute to the discussion on the concern of species loss and habitat destruction in the context of corporate accountability, especially in responding to the sixth mass extinction event and COVID-19 crisis. Our results can also guide the policymakers and stakeholders of the financial market in better decision making. (shrink)

Critical analyses of literatures of the Indian diaspora discuss the “home” of origin as a subtext and a site to which diasporas aspire to return even though it remains an unachievable ideal that is refracted through nostalgic retellings of a space that remains at best “imaginary” (Mishra 2007). Alternatively, some critics, as Roger Waldinger and David Fitzgerald point out, view diasporas’ relationship with the homeland in terms of “loyalty,” obscuring in the process the antagonisms that may arise depending upon one’s (...) circumstances, antagonisms that produce “interactions” between homes of residence and those of origin (2012). In South Asian drama in Canada, many of the concerns regarding race, multiculturalism, job discrimination and violence against women and other marginalized groups are propelled by their links to the playwrights’ “home” of origin. With attention to selected plays, this paper will analyze how the networks between home and spaces of residence in multicultural Canada come alive on theatre stages through visual motifs, actors, props, and photographic collages, which confront the different trajectories of “home” that resurface in these plays. Through live scenes of imagination that speak to spectators, several plays under discussion in this essay expose how, while providing emotional sustenance for some, the baggage of “home” may also pose challenges in the home of residence. So the questions I raise are: How does home appear? To what end? And what does returning “home” teach us about the inequalities and injustices underlying the current global order? (shrink)

Conventional forensic DNA analysis involves a matching principle, which compares DNA profiles from evidential samples to those from reference samples of known origin. In casework, however, the accessibility to a reference sample is not guaranteed which limits the use of DNA as an investigative tool. This has led to the development of phenotype prediction, which uses SNP analysis to estimate the physical appearance of the sample donor. Physical traits, such as eye, hair and skin colour, have been associated with certain (...) alleles within specific genes involved in the melanogenesis pathways. These genetic markers are also associated with ancestry and their trait prediction ability has mainly been assessed in European and North American populations. This has prompted research investigating the discriminatory power of these markers in other populations, especially those exhibiting admixture. South Africa is well known for its diversity, and the viability of these particular SNPs still needs to be assessed within this population. South African law currently restricts the use of DNA for molecular phenotyping, and there are also numerous ethical and social considerations, all of which are discussed. (shrink)

This book is a defense of modal realism; the thesis that our world is but one of a plurality of worlds, and that the individuals that inhabit our world are only a few out of all the inhabitants of all the worlds. Lewis argues that the philosophical utility of modal realism is a good reason for believing that it is true.

A definitive feature of Kant's moral philosophy is its rationalism. Kant insists that moral theory, at least at its foundation, cannot take account of empirical facts about human beings and their circumstances in the world. This is the core of Kant's commitment to ‘metaphysics of morals’, and it is what he sees as his greatest contribution to moral philosophy. The paper clarifies what it means to be committed to metaphysics of morals, why Kant is committed to it, and where he (...) thinks empirical considerations may enter moral theory. The paper examines recent work of contemporary Kantians who argue that there is a central role for empirical considerations in Kant's moral theory. Either these theorists interpret Kant himself as permitting empirical considerations to enter, or they propose to extend Kant's theory so as to allow them to enter. With some qualifications, I argue that these interpretive trends are not supported by the texts, and that the proposed extensions are not plausibly Kantian. Kant's insistence on the exclusion of empirical considerations from the foundations of moral theory is not an incidental feature of his thought which might be modified while the rest remains unchanged. Rather, it is the very centre of his endeavours in moral philosophy. If we disagree with it, I argue, we have grounds for moving to a distinctly different theoretical framework. (shrink)

A historical investigation of the exclusion of Africa and Asia from modern histories of philosophy.

This volume presents six essays by leading sociologists, philosophers, physicists, and environmental activists that examine the links between science and violence from the Baconian era to the present day. It looks at two basic issues: science as it provides a new justification for state violence; and science as violent technological intervention, invading and disrupting stable patterns of private life in the name of progress and development.

There is an argument according to which there must be something nonrelationally valuable for anything to be of value. The chains of dependence between values must come to an end, and humanity meets the specifications. I explore alternatives to terminating a regress in nonrelational value and give reason to reject the “borrowing” conception of relational value that drives the argument. I doubt that the nonrelational value of humanity can be secured by an argument from the structure of value, but I (...) am optimistic about the prospects for explaining our value relationally and give reason to favor a reflexive relational model. (shrink)

The historical mode may be the dominant mode of constructing the past in most parts of the globe but it is certainly not the most popular mode of doing so. The dominance is derived from the links the idea of history has established with the modern nation-state, the secular worldview, the Baconian concept of scientific rationality, nineteenth-century theories of progress and, in recent decades, development. This dominance has also been strengthened by the absence of any radical critique of the idea (...) of history within the modern world and for that matter, within the discipline of history itself. As a result, once exported to the nonmodern world, the historical consciousness has not only tended to absolutize the past in cultures that have lived with open-ended concepts of the past or depended on myths, legends, and epics to define their cultural selves, it has also made the historical worldview complicit with many new forms of violence, exploitation and satanism in our times and helped rigidify civilizational, cultural, and national boundaries. (shrink)

L. Nandi Theunissen offers an original and provocative account of the value of humanity. Human beings have value just as anything of value has value: because we are capable of being of value to someone--in the first place, to ourselves. And this explains the key forms of ethical responsiveness that we owe to one another.

This book brings together a series of interviews conducted by noted Iranian social scientist Ramin Jahanbagloo. These interviews cover the ideas of Indian-ness, Indian thought, religion, politics, secularism, and pluralism, as well as Gandhi, India and Pakistan, democracy, globalization and culture.

This Book Focuses On The Evolution Of Philosophy In India With Reference To Socio-Political And Economic Conditions, Through Which One Can Learn That Life And Thought Are Invariably Interconnected With Polity And Persons, Economy And Environment. This Book Is Unique In The Sense That It Contains A Review In The Conclusion; And The Philosophical Heritage Has Been Evaluated In Its Introduction.

This authoritative volume, written by two well-known psychologist-philosophers, presents a model of the person and its implications for psychological theory and practice. Professors Ramakrishna Rao and Anand Paranjpe draw the contours of Indian psychology, describe the methods of study, explain crucial concepts, and discuss the central ideas and their application, illustrating them with insightful case studies and judicious reviews of available research data and existing scholarly literature. The main theme is organized around the thesis that psychology is the study of (...) the person and that the person is a unique composite of body, mind and consciousness. The goal of the person is self-realization. Self-realization consists in the realization of one's true self as distinct from the manifest ego and it is facilitated by cultivating consciousness. Cultivating consciousness leads to a kind of psycho-spiritual symbiosis resulting in personal transformation, altruistic value orientation and flowering of the hidden human potential. (shrink)

The authors argue that the chain of events which they describe is the end-product of a century's effort to convert Hindus into a 'proper' modern nation and a conventional ethnic majority. Simultaneously, the effort is equally to turn the followers of other Indian faiths into well-behaved ethnic minorities and nationalities. The American model of a 'melting pot' is being imposed with the expectation that it will dissolve India's primordial identities. A society which has for centuries been a salad bowl of (...) diverse communities, each identifiably different but constituting parts of a whole, is being forced to conform to the pattern of a 'proper' nation-state. (shrink)

I once opened a fortune cookie containing the message, ‘All happiness is in the mind’; it is still affixed to my refrigerator. I did not put it there to signal.